1/22/2024 0 Comments Download calciferol d3![]() ![]() Cholecalciferol is needed by the body for healthy bones, muscles, nerves, and to support the immune system. Cholecalciferol (vitamin D 3) is in a class of medications called vitamin D analogs. Cholecalciferol (vitamin D 3) is also used along with calcium to prevent and treat bone diseases such as rickets (softening and weakening of bones in children caused by lack of vitamin D), osteomalacia (softening and weakening of bones in adults caused by lack of vitamin D), and osteoporosis (a condition in which the bones become thin and weak and break easily). People most at risk for vitamin D deficiency are older adults, breastfed infants, people with dark skin, obese people, and those with limited sun exposure, or gastrointestinal disease (GI affecting the stomach or intestines) such as Crohn's disease or celiac disease. ![]() ![]() rickets, osteoporosis, and osteomalacia).Cholecalciferol (vitamin D 3) is used as a dietary supplement when the amount of vitamin D in the diet is not enough. Vitamin D deficiency is a cause of hyperparathyroidism and diseases related to impaired bone metabolism (e.g. Vitamin D plays a major role in calcium and phosphorus homeostasis. A small proportion of the 25(OH)D is further hydroxylated in the kidney, under direct regulation by parathyroid hormone and ionised calcium levels, to form the biologically-active calcitropic hormone 1,25-dihydroxyvitamin D. In the liver, vitamin D is hydroxylated to give 25(OH)D which also circulates as a complex with VDBP. Vitamin D is stored in adipose tissue and enters the circulation bound to vitamin D binding protein (VDBP) and albumin. Approximately 10 – 20 % of vitamin D is supplied through nutritional intake. Main vitamin D sources are: UV exposure from sun which leads to Cholecalciferol production in the upper layers of the skin, foods such as fish, shellfish, mushrooms, vitamin D fortified foods (e.g. Of the two major forms Ergocalciferol (D2) and Cholecalciferol (D3), only vitamin D3 is synthesised by the body. Vitamin D is a fat-soluble steroid pro-hormone. ![]()
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